Difference between revisions of "Hncaco.m"

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{{DISPLAYTITLE:hncaco.m}} __NOTOC__
 
{{DISPLAYTITLE:hncaco.m}} __NOTOC__
 
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Protein-specific HN(CA)CO experiment (Figure 7.41 of "Protein NMR Spectroscopy", 2nd edition) using pre-set values of J-couplings used in the magnetisation transfer stages. The simulation uses the bidirectional propagation method described in (http://dx.doi.org/10.1016/j.jmr.2014.04.002).  
Protein-specific HN(CA)CO experiment (Figure 7.41 of "Protein NMR Spectroscopy", 2nd edition) using pre-set values of J-couplings used in the magnetisation transfer stages. The simulation uses the bidirectional propagation method described in (http://dx.doi.org/10.1016/j.jmr.2014.04.002).
 
  
 
==Syntax==
 
==Syntax==
  
fid=hncaco(spin_system,parameters,H,R,K)
+
    fid=hnca(spin_system,parameters,H,R,K)
  
 
==Arguments==
 
==Arguments==
  
parameters.npoints    - a vector of three integers giving the
+
    parameters.npoints    - a vector of three integers giving the
 
                             number of points in the three temporal
 
                             number of points in the three temporal
 
                             dimensions, ordered as [t1 t2 t3].
 
                             dimensions, ordered as [t1 t2 t3].
 
+
 
     parameters.sweep      - a vector of three real numbers giving
 
     parameters.sweep      - a vector of three real numbers giving
 
                             the sweep widths in the three frequen-
 
                             the sweep widths in the three frequen-
 
                             cy dimensions, ordered as [f1 f2 f3].
 
                             cy dimensions, ordered as [f1 f2 f3].
 
+
    parameters.J_nh        - 1H-15N J-coupling in Hz to be used for
 
                            magnetisation transfer.
 
 
 
    parameters.T          - evolution delay in the indirect 15N
 
                            dimension, in seconds.
 
 
 
    parameters.delta2      - coherence transfer delay in seconds.
 
 
 
 
     H  - Hamiltonian matrix, received from context function
 
     H  - Hamiltonian matrix, received from context function
 
+
 
     R  - relaxation superoperator, received from context function
 
     R  - relaxation superoperator, received from context function
 
+
 
     K  - kinetics superoperator, received from context function
 
     K  - kinetics superoperator, received from context function
  
 
==Outputs==
 
==Outputs==
  
fid - three-dimensional free induction decay
+
    fid - three-dimensional free induction decay
 
 
Note: spin labels must be set to PDB atom IDs ('CA', 'HA', etc.) in
 
      sys.labels for this sequence to work properly.
 
 
 
TODO: whoever understands how phase cycles and quadratures work in
 
      3D NMR is welcome to add a phase-sensitive version.
 
 
 
m.walker@soton.ac.uk
 
ilya.kuprov@weizmann.ac.il
 
  
 
==Examples==
 
==Examples==
 
 
Below is the output (3D spectrum and three projections) of the HN(CA)CO pulse sequence for the GB1 protein (examples/nmr_proteins/hncano_gb1.m).
 
Below is the output (3D spectrum and three projections) of the HN(CA)CO pulse sequence for the GB1 protein (examples/nmr_proteins/hncano_gb1.m).
  
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==Notes==
 
==Notes==
 
 
# The sequence is hard-wired to work on 1H,13C,15N proteins and uses PDB labels to select spins that will be affected by otherwise ideal pulses.
 
# The sequence is hard-wired to work on 1H,13C,15N proteins and uses PDB labels to select spins that will be affected by otherwise ideal pulses.
 
# Channels: F1 is 15N, F2 is 13C, F3 is 1H.
 
# Channels: F1 is 15N, F2 is 13C, F3 is 1H.
Line 57: Line 37:
  
 
==See also==
 
==See also==
 
 
[[Built-in_experiments#Protein_pulse_sequences|Protein pulse sequences]]
 
[[Built-in_experiments#Protein_pulse_sequences|Protein pulse sequences]]
  
  
 
''Version 2.5, authors: [[Matt Walker]], [[Ilya Kuprov]]''
 
''Version 2.5, authors: [[Matt Walker]], [[Ilya Kuprov]]''

Revision as of 15:49, 5 April 2026

Protein-specific HN(CA)CO experiment (Figure 7.41 of "Protein NMR Spectroscopy", 2nd edition) using pre-set values of J-couplings used in the magnetisation transfer stages. The simulation uses the bidirectional propagation method described in (http://dx.doi.org/10.1016/j.jmr.2014.04.002).

Syntax

    fid=hnca(spin_system,parameters,H,R,K)

Arguments

   parameters.npoints     - a vector of three integers giving the
                            number of points in the three temporal
                            dimensions, ordered as [t1 t2 t3].

   parameters.sweep       - a vector of three real numbers giving
                            the sweep widths in the three frequen-
                            cy dimensions, ordered as [f1 f2 f3].

   H   - Hamiltonian matrix, received from context function

   R   - relaxation superoperator, received from context function

   K   - kinetics superoperator, received from context function

Outputs

    fid - three-dimensional free induction decay

Examples

Below is the output (3D spectrum and three projections) of the HN(CA)CO pulse sequence for the GB1 protein (examples/nmr_proteins/hncano_gb1.m).

Hncaco gb1.png

Notes

  1. The sequence is hard-wired to work on 1H,13C,15N proteins and uses PDB labels to select spins that will be affected by otherwise ideal pulses.
  2. Channels: F1 is 15N, F2 is 13C, F3 is 1H.
  3. Spin labels must be set to PDB atom IDs ('CA', 'HA', etc.) in sys.labels for this sequence to work properly

See also

Protein pulse sequences


Version 2.5, authors: Matt Walker, Ilya Kuprov